Publication



OM-X®, fermented vegetables extract suppresses the type I allergy

Date 2016/07/26

Case:Allergy / Immunity

The fermented extract OM-X contributed to suppresses the reaction of type I allergy on allergy model cells and mice

The results of a collaborative research with Kinki University have been published in the Natural Product Communications. 

 

Objective

We conducted a study to evaluate the anti-allergic property of the OM-X extract by using cell and mouse models which is an index of the type I allergy, including asthma and hay fever.

 

Methods

For the evaluation of the anti-allergic property of the OM-X extract, we examined the action of the OM-X extract by looking at the degranulation on rat basophilic leukemia cells (RBL-2H3) which is a model of mast cell and passive cutaneous anaphylaxis reaction (PCA) on mouse models of the type I allergy.

 

Results

<The inhibitory effect against the degranulation of RBL-2H3 cells>

The degranulation that provokes allergic reactions was inhibited in a dose-dependent manner of the OM-X extract.

<The inhibitory effect against the type I allergy (mice)>

In the aspect of PCA reaction in mouse models of the type I allergy, the degree of pigmentation decreased and the allergic reactions were suppressed by an ingestion of the OM-X extract.    




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