Functional Foods in Health and Disease 10,
Metabolomic analysis of SMP30/GNL
knockout mice treated with fermented vegetable and fruit extract (OM-X)
The results of a joint study with Prof.
Koji Wakame et al. of Hokkaido University of Science were published in
Functional Foods in Health and Disease.
We examined the protective effect of OM-X
on liver function by using mice incapable of synthesizing vitamin C within
their bodies (SMP 30/GNL knockout mice), which are known to have functional
Antioxidant activity is decreased in the
mice that cannot synthesize vitamin C in their body and their liver functions
deteriorate. The liver function markers in the blood were measured in the OM-X
group. A metabolome analysis for the liver was also performed in order to comprehensively
analyze genes related to liver function.
The mice that are incapable to synthesize
vitamin C showed a significant increase in transaminases (AST, ALT), which are
indicators of the deterioration of liver function. On the other hand, the rise
of both levels of AST and ALT were significantly suppressed among the mice
administrated with OM-X. Furthermore, metabolomic analysis of the liver
demonstrated that OM-X prevents deterioration of biological functions,
including the reduction of antioxidant capacity and ATP production in vivo in
mice administrated with OM-X.
Last updated 2024/01/23