Collaborative research with Hokkaido University of Science (2018)

[Objective]

We examined whether the OM-X capsules can improve the balance of intestinal microbiota in healthy people who tend to be constipated.

[Methods]

Twenty healthy men and women with a tendency to constipation were divided into two groups: one receiving 3 placebo capsules per day and the other receiving 3 OM-X capsules per day. After 10 days of consumption of each test diet, one month of non-administration period was set. Then, a complete cross-over of test diet with OM-X or placebo were provided to the subjects. Their stools were collected after taking the test diet and the analysis of their intestinal microbiota was conducted on it.

[Results]

Many research papers have reported an increase in the phylum Firmicutes and a decrease in the phylum Bacteroidetes among the intestinal bacteria in obese individuals. Because of the fact that Firmicutes is often considered as the bacteria responsible for weight gain. Through this experiment, the number of Bacteroidetes was significantly increased and Firmicutes was significantly reduced after ingesting OM-X. Based on these results, OM-X can improve the balance of gut microbiota.

Collaborative research with Hokkaido University of Science (2018)

[Objective]

When collagen is synthesized in the body, vitamin C takes an essential role. This study used mice incapable of synthesizing vitamin C in their bodies in order to examine the influence of the administration of OM-X on the synthesis of collagen.

[Methods]

We used mice incapable of synthesizing vitamin C in their bodies. Vitamin C was removed from their feed and OM-X was administered to them for 8 weeks. Thereafter, the levels of type 1 and 17 collagens were measure and verified how the administration of OM-X influences the production of collagen in the mice.

[Results]

Type 1 collagen is mainly related to the elasticity of the skin. Type 17 collagen is at the core of hair follicles and its insufficiency may make hairs thin or gray. Production of both type 1 and type 17 collagen decreased among the mice incapable of synthesizing vitamin C.
On the other hand, the decrease of type1 collagen tended to be suppressed and the reduction of type 17 collagen was significantly prevented among the mice administrated with OM-X.

Joint research with The University of Lille, France (2014)

[Objective]

We created a mouse model of infection with Candida, a type of fungus that causes intestinal infections, and verified the protective effect of OM-X against Candida.

[Methods]

Candida albicans was orally administered in order to prepare the mouse models with candidiasis. Then, we set a group which was given OM-X continuously before and after the inoculation with Candida (preventive treatment model) and a group which was given OM-X only after the inoculation with Candida (curative treatment model). We confirmed the number of Candida infection and intestinal inflammation scores.

[Results]

The inoculated group which did not receive OM-X showed an increment of the number of Candida, but the inoculated groups that were administrated with OM-X for both preventive and curative treatments showed a reduction of the number of Candida infections. As a result of examining the inflammatory scores in the intestines, the inoculated group with no administration of OM-X showed high inflammatory scores. On the other hand, both inoculated groups with the administration of OM-X showed significantly low inflammatory scores. These results suggested that the levels of inflammation in the intestines of mice have been improved.