Joint research with The University of Lille, France (2014)

[Objective]

We created a mouse model of infection with Candida, a type of fungus that causes intestinal infections, and verified the protective effect of OM-X against Candida.

[Methods]

Candida albicans was orally administered in order to prepare the mouse models with candidiasis. Then, we set a group which was given OM-X continuously before and after the inoculation with Candida (preventive treatment model) and a group which was given OM-X only after the inoculation with Candida (curative treatment model). We confirmed the number of Candida infection and intestinal inflammation scores.

[Results]

The inoculated group which did not receive OM-X showed an increment of the number of Candida, but the inoculated groups that were administrated with OM-X for both preventive and curative treatments showed a reduction of the number of Candida infections. As a result of examining the inflammatory scores in the intestines, the inoculated group with no administration of OM-X showed high inflammatory scores. On the other hand, both inoculated groups with the administration of OM-X showed significantly low inflammatory scores. These results suggested that the levels of inflammation in the intestines of mice have been improved.