Journal of Functional Foods 97, 105228 (2022)

Anti-fatigue effect of OM-X, fermented plant extract with lactic acid bacteria and bifidobacterial: A randomized, placebo-controlled, double-blind, comparative study

 [Objective]

In modern society, an increasing number of people suffer from chronic fatigue. We examined the anti-fatigue effect of the OM-X capsules on 38 healthy Japanese men and women who felt fatigue.
[Methods]
Japanese men and women were divided into two groups, one taking the OM-X capsules and the other taking placebo, each group took 3 capsules per day continuously for 12 weeks. The fatigue sensation was measured before and after the test, and blood samples were taken to measure antioxidants in the blood.
[Results]
Compared to the placebo group, the OM-X capsule group showed a significant reduction in the fatigue sensation after 12 weeks of intake, both in terms of change in VAS (Visual analog scale) and CFS (Chalder fatigue scale).
The blood antioxidants level after 12 weeks of intake was also significantly improved in the OM-X capsule group.

Functional Foods in Health and Disease 10, 95-110 (2020)

Metabolomic analysis of SMP30/GNL knockout mice treated with fermented vegetable and fruit extract (OM-X)

The results of a joint study with Prof. Koji Wakame et al. of Hokkaido University of Science were published in Functional Foods in Health and Disease.

 [Objective]

We examined the protective effect of OM-X on liver function by using mice incapable of synthesizing vitamin C within their bodies (SMP 30/GNL knockout mice), which are known to have functional liver deterioration.

[Methods]

Antioxidant activity is decreased in the mice that cannot synthesize vitamin C in their body and their liver functions deteriorate. The liver function markers in the blood were measured in the OM-X group. A metabolome analysis for the liver was also performed in order to comprehensively analyze genes related to liver function.

[Results]

The mice that are incapable to synthesize vitamin C showed a significant increase in transaminases (AST, ALT), which are indicators of the deterioration of liver function. On the other hand, the rise of both levels of AST and ALT were significantly suppressed among the mice administrated with OM-X. Furthermore, metabolomic analysis of the liver demonstrated that OM-X prevents deterioration of biological functions, including the reduction of antioxidant capacity and ATP production in vivo in mice administrated with OM-X.

Natural Product Communications. 12, 111-114 (2017)

OM-X®, a Fermented Vegetables Extract, Facilitates Muscle Endurance Capacity in Swimming Exercise Mice

The results of a collaborative research with associate professor Tomohiro Itoh and his colleagues from the Graduate School of Bioresources at Mie University have been published in the Natural Product Communications.  

【Objective】

We conducted a study to evaluate an anti-fatigue effect and the enhancement of muscle endurance by dosing the fermented vegetable extract (OM-X) to mice. 

【Methods】

We compared the duration of the forced swimming between the mice which were dosed with OM-X daily and the mice which were not dosed with OM-X. The forced swimming tests were conducted once a week for 4 weeks. We set their swimming duration which was recorded at the first week as 100% and evaluated their swimming duration at the second week or after to confirm whether it was shorter or longer than the based time. We also measured the level of the enzyme which is used for the metabolism of fatigue-related substances (ammonia) in the liver of the mice.

【Results】

The swimming duration of the mice which were not dosed with OM-X decreased to about 40% at the second week compared to their swimming duration at the first week. However, the mice which were dosed with OM-X maintained about 65% of their swimming duration. Furthermore, the swimming duration of the mice without OM-X decreased to about 50% at the fourth week. However, the swimming duration of the mice with OM-X prolonged more than their record at the first week.

We analyzed the liver of the mice as well and found that the mice with OM-X showed an increase in the gene expression of the enzyme which is used for the metabolism of fatigue-related substances (ammonia) when compared to the mice without OM-X. On the basis of these results, we consider that the ingestion of OM-X enhances the metabolism of fatigue-related substances which results in the extension of the swimming duration of the mice.