Date 2017/02/23
Case:Athletic ability
The ingestion of the fermented vegetable extract (OM-X) contributes to the anti-fatigue effect and the enhancement of muscle endurance.
Natural Product Communications. 12, 111-114 (2017)
OM-X®, a Fermented Vegetables Extract, Facilitates Muscle Endurance Capacity in Swimming Exercise Mice
The results
of a collaborative research with associate professor Tomohiro Itoh and his
colleagues from the Graduate School of Bioresources at Mie University have been
published in the Natural Product Communications.
【Objective】
We conducted a study to evaluate an
anti-fatigue effect and the enhancement of muscle endurance by dosing the
fermented vegetable extract (OM-X) to mice.
【Methods】
We compared the duration of the forced
swimming between the mice which were dosed with OM-X daily and the mice which
were not dosed with OM-X. The forced swimming tests were conducted once a week
for 4 weeks. We set their swimming duration which was recorded at the first
week as 100% and evaluated their swimming duration at the second week or after to
confirm whether it was shorter or longer than the based time. We also measured the
level of the enzyme which is used for the metabolism
of fatigue-related substances (ammonia) in
the liver of the mice.
【Results】
The swimming duration of the mice
which were not dosed with OM-X decreased to about 40% at
the second week compared to their swimming duration at the first week. However,
the mice which were dosed with OM-X maintained about 65% of their swimming duration.
Furthermore, the swimming duration of the mice without OM-X decreased to about
50% at the fourth week. However, the swimming duration of the mice with OM-X
prolonged more than their record at the first week.
We
analyzed the liver of the mice as well and found that the mice with OM-X showed
an increase in the gene expression of the enzyme which is used for the metabolism
of fatigue-related substances (ammonia) when compared to the mice without OM-X.
On the basis of these results, we consider that the ingestion of OM-X enhances the
metabolism of fatigue-related substances which results in the extension of the
swimming duration of the mice.